William Henry Harrison (1841)[]
- Whig
- VP: John Tyler
- Secretary of State: Daniel Webster
- Major items:
- None. Died thirty days after taking office
John Tyler (1841-1845)[]
- Anti-Jackson Democrat who ran on as Harrison's VP on the Whig ticket
- Secretary of State: Daniel Webster
- Major items:
- Webster-Ashburton Treaty, 1842
- Vetoes Clay's bill for the Third Bank of the United States
- Canadian border set at 45th parallel
James K. Polk (1845-1849)[]
- A "dark horse candidate"
- Democrat
- VP: George Dallas
- Major items:
- Manifest Destiny doctrine becomes popular
- Texas becomes a state, 1845
- Oregon boundary settled, 1846
- Mexican-American War, 1846-1848
- Treaty of Guadeloupe-Hidalgo, 1848
- Wilmot Proviso
Zachary Taylor (1849-1850)[]
- Whig
- VP: Millard Fillmore
- Major items:
- None. Died.
Millard Fillmore (1850-1853)[]
- Whig
- Secretary of State: Daniel Webster
- Major items:
- Compromise of 1850
- Clayton-Bulwer Treaty, 1850
- Uncle Tom's Cabin, 1852
Franklin Pierce, 1853-1857[]
- Democrat
- VP: William King
- Major items:
- Kansas-Nebraska Act, 1864
- Popular soveriegnty implemented
- Japan opened to world trade, 1853
- Underground Railroad
- Bleeding Kansas
- Onsted Manifesto, 1854
James Buchanan (1857-1861)[]
- Democrat
- VP: John C. Breckinridge
- Major items:
- Dred Scott decision, 1857
- Lincoln-Douglas Debates, 1858
- Civil War, 1861-1865
Abraham Lincoln (1861-1865)[]
- Republican
- VP: Hannibal Hamlin, Andrew Johnson
- Secretary of State: William H. Seward
- Secretary of the Treasury: Salmon P. Chase
- Secretary of War: Edwin M. Stanton
- Major items:
- Civil War, 1861-1865
- Emancipation Proclamation, 1863
- Homestead Act, 1862
- Morill Act, 1862
- Assassinated on April 15th, 1865, by John Wilkes Booth